Slow-Release Technique of Dexamethasone Implant
نویسندگان
چکیده
منابع مشابه
Ozurdex® (a slow-release dexamethasone implant) in proliferative vitreoretinopathy: study protocol for a randomised controlled trial
BACKGROUND Proliferative vitreoretinopathy (PVR) is the commonest cause of late anatomical failure in rhegmatogenous retinal detachment. Visual and anatomical outcomes remain poor despite advances in vitreoretinal surgical techniques with reported primary failure rates of up to nearly 50%. Numerous adjunctive medications have been evaluated in clinical trials with no agent gaining widespread ac...
متن کاملPharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant.
PURPOSE To determine the pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone (DEX) intravitreal implant (Ozurdex; Allergan, Inc.). METHODS Thirty-four male monkeys (Macaca fascicularis) received bilateral 0.7-mg DEX implants. Blood, vitreous humor, and retina samples were collected at predetermined intervals up to 270 days after administration. DEX was quantified by liq...
متن کاملExperimental study of PLLA/INH slow release implant fabricated by three dimensional printing technique and drug release characteristics in vitro
BACKGROUND Local slow release implant provided long term and stable drug release in the lesion. The objective of this study was to fabricate biodegradable slow release INH/PLLA tablet via 3 dimensional printing technique (3DP) and to compare the drug release characteristics of three different structured tablets in vitro. METHODS Three different drug delivery systems (columnar-shaped tablet (C...
متن کاملEvaluation of Madurahydroxylactone as a Slow Release Antibacterial Implant Coating
Madurahydroxylactone (MHL), a secondary metabolite with antibacterial activity was evaluated for its suitability to generate controlled drug release coatings on medical implant materials. A smooth and firmly attached layer could be produced from a precursor solution on various metallic implant materials. In physiological salt solutions these coatings dissolved within a time period up to one wee...
متن کاملClinical applications of the sustained-release dexamethasone implant for treatment of macular edema
Macular edema is one of the leading causes of vision loss among patients with retinal vein occlusion, diabetic retinopathy, and posterior chamber inflammatory disease. However, the treatment of macular edema is considerably limited by the difficulty in delivering effective doses of therapeutic agents into the vitreous cavity. In recent years, the development of a sustained-release dexamethasone...
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ژورنال
عنوان ژورنال: Acta Scientific Ophthalmology
سال: 2021
ISSN: 2582-3191
DOI: 10.31080/asop.2021.04.0295